PROJECT SUMMARY The purpose of the Program is to bring together a team of investigators to focus on the pathobiology of two important disease states, Chronic Lung Allograft Dysfunction and idiopathic pulmonary fibrosis using both state-of-the-art animal modeling and human samples. The goals of this Program are to improve our understanding of the mechanisms that contribute to disease progression and identity novel therapeutic targets to combat lung fibrosis whether it occurs in the airway or in the interstitium of the lung. The Program brings together a team of scientists and physician scientists with complementary skills to work as a unit on these important problems. In order to coordinate these efforts, we propose an Administrative Core to facilitate interactions and adherence to NIH regulations regarding management of PO1 proposals. We propose the following Specific Aims: ? Coordinate and facilitate administration of the Program between Project Leaders and Core Leaders. ? Coordinate and facilitate administration of the Program between investigators, internal and external advisors and an enrichment program organized to maximize scientific productivity.